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1

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

Fienberg, Stephen, Cozier, Gyles E., Acharya, K. Ravi, Chibale, Kelly, Sturrock, Edward D.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.31 MB

english, 2018

2

Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis

Njogu, Peter M., Guantai, Eric M., Pavadai, Elumalai, Chibale, Kelly

Journal:

ACS Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 903 KB

english, 2015

3

Synthesis and biological characterisation of ester and amide derivatives of Fusidic acid as antiplasmodial agents

Singh, Kawaljit, Espinoza-Moraga, Marlene, Njoroge, Mathew, Kaur, Gurminder, Okombo, John, De Kock, Carmen, Smith, Peter J., Wittlin, Sergio, Chibale, Kelly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 474 KB

english, 2016

4

Stuart Warren (24 Dec 1938â22 Mar 2020)

Aggarwal, Varinder K., Armstrong, Susan K., Caggiano, Lorenzo, Chibale, Kelly, Clayden, Jonathan, Coldham, Iain, Greeves, Nicholas, Hartley, Richard C., Knight, Julian G., Kuhnert, Nikolai, Mitchell,

Journal:

Organic & Biomolecular Chemistry

Year:

2020

File:

PDF, 319 KB

2020

5

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives

Idan Chiyanzu, Cailean Clarkson, Peter J. Smith, Julie Lehman, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 235 KB

english, 2005

6

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

Eric M. Guantai, Kanyile Ncokazi, Timothy J. Egan, Jiri Gut, Philip J. Rosenthal, Peter J. Smith, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

7

Synthesis and molecular modeling of a lisinopril–tryptophan analogue inhibitor of angiotensin I-converting enzyme

Aloysius T. Nchinda, Kelly Chibale, Pierre Redelinghuys, Edward D. Sturrock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

8

Meclonazepam analogues as potential new antihelmintic agents

Aman Mahajan, Vipan Kumar, Nuha R.N. Mansour, Quentin Bickle, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 130 KB

english, 2008

9

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

Renate H. Hans, Eric M. Guantai, Carmen Lategan, Peter J. Smith, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 210 KB

english, 2010

10

Synthesis and antimalarial activity in vitro of new heterobimetallic complexes: Rh and Au derivatives of chloroquine and a series of ferrocenyl-4-amino-7-chloroquinolines

Margaret A.L Blackie, Paul Beagley, Kelly Chibale, Cailean Clarkson, John R Moss, Peter J Smith

Journal:

Journal of Organometallic Chemistry

Year:

2003

Language:

english

File:

PDF, 360 KB

english, 2003

11

Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum

Tzu-Shean Feng, Eric M. Guantai, Margo Nell, Constance E.J. van Rensburg, Kanyile Ncokazi, Timothy J. Egan, Heinrich C. Hoppe, Kelly Chibale

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.10 MB

english, 2011

12

Synthesis, Characterization, and Pharmacological Evaluation of Silicon-Containing Aminoquinoline Organometallic Complexes As Antiplasmodial, Antitumor, and Antimycobacterial Agents

Li, Yiqun, de Kock, Carmen, Smith, Peter J., Guzgay, Hajira, Hendricks, Denver T., Naran, Krupa, Mizrahi, Valerie, Warner, Digby F., Chibale, Kelly, Smith, Gregory S.

Journal:

Organometallics

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

13

Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone–Chloroquine Hybrids

Andayi, Warren A., Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Chibale, Kelly

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

14

Structure–activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods

Nsumiwa, Samkele, Kuter, David, Wittlin, Sergio, Chibale, Kelly, Egan, Timothy J.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

15

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

Ghidelli-Disse, Sonja, Lafuente-Monasterio, Maria, Waterson, David, Witty, Michael, Younis, Yassir, Paquet, Tanya, Street, Leslie J, Chibale, Kelly, Gamo-Benito, Francisco, Bantscheff, Marcus, Drewes,

Journal:

Malaria Journal

Year:

2014

Language:

english

File:

PDF, 246 KB

english, 2014

16

Crystallisation of an Unexpected Trinuclear Heteronuclear Carbosilane Congener of Ferroquine

Li, Yiqun, Chibale, Kelly, Smith, Gregory S.

Journal:

Journal of Chemical Crystallography

Year:

2015

Language:

english

File:

PDF, 638 KB

english, 2015

17

Book Review, The Organic Chemistry of Drug Synthesis, Volume 6

Journal:

Year:

2000

Language:

english

File:

PDF, 24 KB

english, 2000

18

2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization.

Murugesan, Dinakaran, Ray, Peter C., Bayliss, Tracy, Prosser, Gareth A., Harrison, Justin R., Green, Kirsteen, Soares de Melo, Candice, Feng, Tzu-Shean, Street, Leslie J., Chibale, Kelly, Warner, Digb

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

19

Mathematical analysis of a model for the transmission dynamics of Trichomonas vaginalis (TV) and HIV coinfection

Garba, Salisu M., Mumba, Chibale K.

Journal:

Mathematical Methods in the Applied Sciences

Year:

2018

Language:

english

File:

PDF, 1.00 MB

english, 2018

20

Metallocene Antimalarials: The Continuing Quest

Blackie, Margaret A. L., Chibale, Kelly

Journal:

Metal-Based Drugs

Year:

2008

Language:

english

File:

PDF, 956 KB

english, 2008

21

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

Cheuka, Peter, Mayoka, Godfrey, Mutai, Peggoty, Chibale, Kelly

Journal:

Year:

2016

Language:

english

File:

PDF, 3.59 MB

english, 2016

22

Structure-activity relationship and in vitro ADMET studies of N-aryl 3-trifluoromethyl pyrido [1,2-a] benzimidazoles that are efficacious in a mouse model of schistosomiasis.

Mayoka, Godfrey, Keiser, Jennifer, Haeberli, Cecile, Chibale, Kelly

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 495 KB

english, 2018

23

[Annual Reports in Medicinal Chemistry] Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases Volume 53 || Preface

Year:

2019

File:

PDF, 25 KB

2019

24

Thiosemicarbazone Salicylaldiminato-Palladium(II)-Catalyzed Mizoroki–Heck Reactions

Guanlei Xie, Prinessa Chellan, Jincheng Mao, Kelly Chibale, Gregory S. Smith

Journal:

Advanced Synthesis & Catalysis

Year:

2010

Language:

english

File:

PDF, 169 KB

english, 2010

25

ChemInform Abstract: Kinetic Resolution in Asymmetric anti Aldol Reactions of Branched and Straight Chain Racemic 2-Phenylsulfanyl Aldehydes: Asymmetric Synthesis of Cyclic Ethers and Lactones by Phenylsulfanyl Migration.

K. CHIBALE, S. WARREN

Journal:

Year:

1997

File:

PDF, 31 KB

1997

26

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Carbohydrate-Based Mimetics of cRGDFV.

K. C. NICOLAOU, J. I. TRUJILLO, K. CHIBALE

Journal:

Year:

1997

File:

PDF, 31 KB

1997

27

ChemInform Abstract: Synthesis and Evaluation of 9,9-Dimethylxanthene Tricyclics Against Trypanothione Reductase, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani.

Kelly Chibale, Mark Visser, Vanessa Yardley, Simon L. Croft, Alan H. Fairlamb

Journal:

Year:

2000

File:

PDF, 28 KB

2000

28

ChemInform Abstract: Antiprotozoal and Cytotoxicity Evaluation of Sulfonamide and Urea Analogues of Quinacrine.

Kelly Chibale, Hayley Haupt, Howard Kendrick, Vanessa Yardley, Ahilan Saravanamuthu, Alan H. Fairlamb, Simon L. Croft

Journal:

Year:

2002

File:

PDF, 30 KB

2002

29

ChemInform Abstract: A Novel and Efficient Regiospecific Preparation of Arenesulfonamide Derivatives of 3,5-Diamino-1,2,4-triazole.

Kelly Chibale, Jerome Dauvergne, Paul G. Wyatt

Journal:

Year:

2002

File:

PDF, 30 KB

2002

30

Synthesis and Evaluation of Isatins (V) and Thiosemicarbazone Derivatives (I) Against Cruzain, Falcipain-2 and Rhodesain.

Idan Chiyanzu, Elizabeth Hansell, Jiri Gut, Philip J. Rosenthal, James H. McKerrow, Kelly Chibale

Journal:

Year:

2004

File:

PDF, 87 KB

2004

31

Unprecedented Observation of Sulfonamides in the Transesterification of N-Unsubstituted Carbamates with Sulfonyl Chlorides.

Jerome Dauvergne, Kevin Wellington, Kelly Chibale

Journal:

Year:

2004

File:

PDF, 83 KB

2004

32

Application of Multi-Component Reactions to Antimalarial Drug Discovery. Part 1. Parallel Synthesis and Antiplasmodial Activity of New 4-Aminoquinoline Ugi Adducts.

Chitalu C. Musonda, Dale Taylor, Julie Lehman, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Year:

2004

File:

PDF, 21 KB

2004

33

ChemInform Abstract: A New and Simple Synthesis of Sulfonyl Ureas from Sulfonamides and N-Alkyl-1,2,4-dithiazolidine-3,5-diones.

Richard K. Gessner, Kelly Chibale

Journal:

Year:

2010

File:

PDF, 33 KB

2010

34

ChemInform Abstract: Thiosemicarbazone Salicylaldiminato-Palladium(II)-Catalyzed Mizoroki—Heck Reactions.

Guanlei Xie, Prinessa Chellan, Jincheng Mao, Kelly Chibale, Gregory S. Smith

Journal:

Year:

2010

File:

PDF, 25 KB

2010

35

ChemInform Abstract: Synthesis of 2-(Aminomethyl)aziridines and Their Microwave-Assisted Ring Opening to 1,2,3-Triaminopropanes as Novel Antimalarial Pharmacophores.

Matthias D'hooghe, Sara Kenis, Karel Vervisch, Carmen Lategan, Peter J. Smith, Kelly Chibale, Norbert De Kimpe

Journal:

Year:

2011

Language:

english

File:

PDF, 77 KB

english, 2011

36

ChemInform Abstract: Facile Transformation of Biginelli Pyrimidin-2(1H)-ones to Pyrimidines. In vitro Evaluation as Inhibitors of Mycobacterium tuberculosis and Modulators of Cytostatic Activity.

Kamaljit Singh, Kawaljit Singh, Baojie Wan, Scott Franzblau, Kelly Chibale, Jan Balzarini

Journal:

Year:

2011

File:

PDF, 37 KB

2011

37

ChemInform Abstract: Antiplasmodial and Antitumor Activity of Dihydroartemisinin Analogues Derived via the Aza-Michael Addition Reaction.

Tzu-Shean Feng, Eric M. Guantai, Margo J. Nell, Constance E. J. van Rensburg, Heinrich C. Hoppe, Kelly Chibale

Journal:

Year:

2011

File:

PDF, 29 KB

2011

38

Reversed Chloroquines Based on the 3,4-Dihydropyrimidin-2(1H)-one Scaffold: Synthesis and Evaluation for Antimalarial, β-Haematin Inhibition, and Cytotoxic Activity

Natasha October, Nicholas D. Watermeyer, Vanessa Yardley, Timothy J. Egan, Kanyile Ncokazi, Kelly Chibale

Journal:

Year:

2008

Language:

english

File:

PDF, 201 KB

english, 2008

39

Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents

Prinessa Chellan, Nelusha Shunmoogam-Gounden, Denver T. Hendricks, Jiri Gut, Philip J. Rosenthal, Carmen Lategan, Peter J. Smith, Kelly Chibale, Gregory S. Smith

Journal:

European Journal of Inorganic Chemistry

Year:

2010

Language:

english

File:

PDF, 424 KB

english, 2010

40

Effect of Varying the Anionic Component of a Copper(I) Catalyst on Homologation of Arylacetylenes to Allenes by the Mannich Reaction

Vipan Kumar, Alex Chipeleme, Kelly Chibale

Journal:

European Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 171 KB

english, 2008

41

Asymmetric synthesis of spirocyclic pyrrolidines and tetrahydrofurans by chiral aldol reactions and phenylthio migration

Kelly Chibale, Stuart Warren

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 238 KB

english, 1991

42

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline γ- and δ-lactams via a ‘catch and release’ protocol

Chitalu C. Musonda, Jiri Gut, Philip J. Rosenthal, Vanessa Yardley, Renata C. Carvalho de Souza, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 213 KB

english, 2006

43

Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents

Aman Mahajan, Susan Yeh, Margo Nell, Constance E.J. van Rensburg, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 122 KB

english, 2007

44

Comparison of the antiplasmodial and falcipain-2 inhibitory activity of β-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids

Renate H. Hans, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 299 KB

english, 2010

45

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum

Alex Chipeleme, Jiri Gut, Philip J. Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 210 KB

english, 2007

46

Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum

Margaret A.L. Blackie, Paul Beagley, Simon L. Croft, Howard Kendrick, John R. Moss, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 193 KB

english, 2007

47

Synthetic medicinal chemistry of selected antimalarial natural products

Vipan Kumar, Aman Mahajan, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.68 MB

english, 2009

48

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

Chitalu C Musonda, Dale Taylor, Julie Lehman, Jiri Gut, Philip J Rosenthal, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

49

Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors

Aloysius T. Nchinda, Kelly Chibale, Pierre Redelinghuys, Edward D. Sturrock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 108 KB

english, 2006

50

Application of multicomponent reactions to antimalarial drug discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro

Chitalu C. Musonda, Susan Little, Vanessa Yardley, Kelly Chibale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 130 KB

english, 2007